I will present a multi-wavelength survey of distant (1.3 < z < 2.6) luminous quasars aimed to study their host galaxies using the Keck integral field spectrograph (IFS) OSIRIS and laser guide star adaptive optics (LGS-AO) system, ALMA, HST and VLA. Studying distant quasar host galaxies is essential for understanding the role of active galactic nuclei (AGN) feedback on the interstellar medium (ISM), and its capability of regulating the growth of the galaxy and supermassive black hole (SMBH). The combination of LGS-AO and OSIRIS affords the necessary spatial resolution and contrast to disentangle the bright quasar emission from that of its faint host galaxy. We resolve the nebular emission lines Hβ, [OIII], [NII], Hα and [SII] at a sub-kiloparsec resolution to study the distribution, kinematics, and dynamics of the warm-ionized ISM in the host galaxy. One of the primary survey goals is to study ionized outflows and relate their spatial extent and energetics to the star-forming properties of the host galaxy. Combining ALMA and OSIRIS, we directly test whether outflows detected with OSIRIS are affecting the molecular ISM. We are now obtaining detailed observations of the circumgalactic medium (CGM) of these systems with the newly commissioned Keck Cosmic Web Imager (KCWI). The gas in the CGM may play an essential role in the evolution of these galaxies. I will show preliminary results from deep observation on several sources taken over the last year.